Grace et al., 2016. Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proc Natl Acad Sci USA. (accepted).
Grace et al., 2014. Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience, 280C, pp.299–317.
Grace et al., 2016. Prior voluntary wheel running attenuates neuropathic pain. PAIN. (accepted)
Pain: hitting where it hurts. pdf
Exercise Provides Protection Against Inflammation—and Pain
Emergency Medical Minute Podcast: Do opioids cause chronic pain?
Naked Scientists Podcast: Could painkillers cause pain?
Our latest paper published in the Proceedings of the National Academy of Sciences USA, showing that morphine may prolong neuropathic pain in rats, is available here
Why taking morphine, oxycodone can sometimes make pain worse
Radio interview: Opioids like morphine could make some chronic pain worse
Opioid paradox: Could morphine use hurt as much as it helps by prolonging chronic pain?
ABC News 24: Chronic pain and opioids
The Pain Research Forum has covered our work showing that aerobic exercise can help prevent chronic pain